Technical Papers

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Journal Publications for Shelley Medical Imaging Technologies Products

Computer Controlled Physiological Flow Pumps & Carotid Bifurcation Phantoms:

D.W. Holdsworth, D.W. Rickey, M. Drangova, D.J.M. Miller, A. Fenster, "Computer-controlled positive displacement pump for physiological flow simulation," Med. Biol. Eng. Comp., 29, 565-570(1991)  [PubMed Abstract]
Napel, S., Dunne, S., Rutt, B.K., "Fast Fournier Projection for MR Angiography," MRM 19: 393-405 (1991)
Rutt, B.K., Napel, S., "Magnetic Techniques for Blood Flow Measurement and Vascular Imaging," Journal of The Canadian Association of Radiologists 42: 21-30 (1991)  [PubMed Abstract]
Napel, S., Lee, D.H., Frayne, R., and Rutt, B.K., Visualizing Flow in 3D Using Simulated Streamline and 3D Phase Contrast MRI," JMRI 2: 143-153 (1992)
Richard Frayne, David W. Holdsworth, Linda Gowman, Daniel Rickey, Maria Drangova, Aaron Fenster, Brian Rutt, "Computer-controlled Flow Simulator for MR Flow Studies," JMRI … 2 … 605-612(1992)  [PubMed Abstract]
Richard Frayne, Linda M. Gowman, Daniel W. Rickey, David W. Holdsworth, Paul A. Picot, Maria Drangova, Ken Chu, Curtis B. Caldwell, Aaron Fenster, Brian K. Rutt, "A geometrically accurate vascular phantom for comparative studies of x-ray, ultrasound, and magnetic resonance vascular imaging: construction and geometrical verification," Med. Phys. 20, 415 - 425 (1993)
Frayne, R., Rutt, B.K., "Frequency Response of Retrospectively Gated Phase Contrast MRI: Effect of Interpretation," JMRI 3: 907-917 (1993)
Frayne, R., Holdsworth, D.W., Smith, R.F., Kasrai, R., Larsen, P.T., and Rutt, B.K., "Turbine flow sensor for volume-flow rate verification in MR,"Mag. Reson. Med. 32, 410-417 (1994)  [PubMed Abstract]
Lauzon, M., Holdsworth, D.W., Frayne, R., and Rutt, B.K., "Effects of physiological waveform variability in gated MRI: A theoretical understanding," J Mag. Reson. Imag., 4, 853-867 (1994)
Frayne, R., Steinman, D.A., Ethier, C.R., Rutt, B.K., Accuracy of MR Phase Contrast Velocity Measurements for Unsteady Flow," JMRI 5 (4): 428-431 (1995)  [PubMed Abstract]
Frayne, R., Rutt, B.K., "Measurement of Fluid Shear Rate by Fournier-Encoded Velocity Imaging," MRM 34: 378-387 (1995)
Frayne, R., Rutt, B.K., "Frequency Response of Prospectively-Gated Phase Contrast MR Imaging," JMRI 5: 65-73 (1995)  [PubMed Abstract]
Frayne, R., Rutt, B.K., "Understanding Acceleration-induced Displacent Artifacts in Phase-Contrast MR Velocity Measurements," JMRI 5: 207-215 (1995)  [PubMed Abstract]
Halpern, EJ, MD, Deane, CR, Needleman, L, Merton, DA, East, SA "Normal Renal Artery Spectral Doppler Waveform: A Closer Look," Radiology 196 : 667- 673 (1995)
 Bakker, CJ, Kouwenhoven, M, Hartkamp, MJ, Hoogeveen, RM, And Mali, WPTM, "Accuracy And Precision Of Time-Averaged Flow As Measured By NonTriggered 2D Phase-Contrast MR Angiography, A Phantom Evaluation," Magnetic Resonance Imaging, Vol. 13, No. 7, 959 - 965 (1995)
Guo, Z, Moreau, M, Rickey, DW, Picot, PA, Fenster, A, "Quantitative Investigation of In Vitro Flow Using Three-Dimensional Colour Doppler Ultrasound"  Ultrasound Med Biol 21: No. 6, pp. 807-816, 1995
Bohs LN, Friemel BH, Trahey GE, "Experimental velocity profiles and volumetric flow via two-dimensional speckle tracking," Ultrasound Med Biol 21: (7):885-98 (1995)  [PubMed Abstract]
Rickey, DW, Picot, PA, Christopher, DA, Fenster, A, "A Wall-Less Vessel Phantom For Doppler Ultrasound Studies"  Ultrasound Med. & Biol., Vol 21, No. 9, pp. 1163-1176, 1995
Picot, PA, Fruitman, M, Rankin, RN, Fenster, A, "Rapid Volume Flow Rate Estimation Using Transverse Colour Doppler Imaging" Ultrasound Med. & Biol., Vol. 21, No. 9, pp 1199-1209, (1995) [PubMed Abstract]
Steinman, D.A., Frayne, R., Zhang, X-D, Rutt, B.K., Ethier, C.R., "MR Measurements and Numerical Simulation of Steady Flow in an End-to-side Anastomosis Model," Journal of Biomechanics29: 537-542 (1996) [PubMed Abstract]
Smith, R.F., Rutt, B.K., Fox, A., Rankin, R.N., Holdsworth, D.W., "Geometric Characterization of Stenosed Human Carotid Arteries," Acad.Radiol. 3 ; 898 - 911 (1996) [PubMed Abstract]
Rickey, DW, Fenster, A, "Evaluation of An Automated Real-Time Spectral Analysis Technique"  Ultrasound in Med. & Biol Vol. 22, No. 1, pp. 61-73 (1996)
Guo, Z. and Fenster, A., "Three-Dimensional Power Doppler Imaging: A Phantom Study To Qualify Vessel Stenosis," Ultrasound in Med. & Biol., Vol. 22, No. 8, pp. 1059 - 1069 (1996)
Drangova, M., Pelc, N.J., "Artifacts and Signal Loss Due To Flow in the Presence of Bo Inhomogeneity" MRM 35: 126-130 (1996)
Bakker, CJ, Romhild M. Hoogeveen, Weber, J, van Vaals, JJ, Viergever, MA Mali, WP "Visualization of dedicated catheters using fast scanning techniques with potential for MR-guided vascular interventions," MRM 36 : 816 - 820 (1996)  [PubMed Abstract]
Chu, K.C., Rutt, B.K., "Polyvinyl Alcohol Cryogel: An Ideal Phantom Material for MR Studies of Arterial Flow and Elasticity," MRM 37: 314-319 (1997)
Hoogeveen, RM, Bakker, CJ, Viergeveer, MA, "Phase-Derivative Analysis in MR Angiography: Reduced Venc Dependency and Improved Vessel Wall Detection in Laminar and Disturbed Flow," JMRI 7 : 321 - 330 (1997)
Steinman, D., Ethier, C.R., Rutt, B.K., "Combined Analysis of Spatial and Velocity Displacement Artifacts in Phase Contrast Measurements of Complex Flows," JMRI 7: 339-346 (1997) [PubMed Abstract]
Lamothe M.J.R., Rutt, B.K., "Multi-Step Phase Difference Phase Contrast Imaging," JMRI 7: 838-842 (1997)
Smith, R.F., Rutt, B.K., and Holdsworth, D.W., "Anthropomorphic carotid bifurcation phantom for MRI applications," (Accepted November 1997)  [PubMed Abstract]
Poutanen, VP, Kivisaari, R, Hakkinen, AR, Savolainen, S, Hekali, P, Standertskj–ld-Nordenstam, CG."Multiphase Segmented K-space Velocity Mapping in Pulsatile Flow Waveforms," Magnetic Resonance Imaging, 16 (3), pp. 261-270 (1997)  [PubMed Abstract]
Lee, M.K., Drangova, M., Holdsworth D.W., and Fenster, A., "Application of dynamic computed tomography for measurements of local aortic elastic modulus," Med. Biol. Eng. Comput., 37, 13-24 (1998)   [PubMed Abstract]
Stewart, SF, Burté F, Clark RE. "Aliasing-tolerant color Doppler quantification of regurgitant jets," UMB, 24:881-898 (1998)   [PubMed Abstract]
Steinman, DA, Rutt, BK "On the nature and reduction of plaque-mimicking flow artifacts in black blood MRI of the carotid bifurcation," Magn. Res. Med. Apr; 39 (4): 635-41 (1998)   [PubMed Abstract]
Moore, J.A., Steinman, D.A., Ethier, C.R., "Computational blood flow modeling: errors associated with reconstructing finite element models from magnetic resonance images," J. Biomech. 31 (2) 179-184 (1998)
Guo, Z, Durand, LG, Allard, L, Cloutier, G, Fenster, A, "In vitro evaluation of multiple arterial stenoses using three-dimensional power Doppler angiography," J. Vasc. Surg. Apr; 27 (4): 681-688(1998)  [PubMed Abstract]
Milner, JS, Moore, JA, Rutt, BK, Steinman, DA, "Hemodynamics of human carotid artery bifurcations: computational studies with models reconstructed from magnetic resonance imaging of normal subjects," J Vasc Surg Jul; 28 (1): 143-156 (1998)  [PubMed Abstract]
Liu, K, Rutt, BK, "Sliding interleaved kY (SLINKY) acquisition: a novel 3D MRA technique with suppressed slab boundary artifact," JMRI Jul-Aug; 8 (4): 903-911 (1998)  [PubMed Abstract]
Liu, K, Lee, DH, Rutt, BK, "Systematic assessment and evaluation of sliding interleaved kY (SLINKY) acquisition for 3D MRA," JMRI Jul-Aug;8 (4): 912-923 (1998)  [PubMed Abstract]
Liu, K., Tanttu, J., Castren, A., Rutt, B.K., "Scanning Time Efficient SLINKY for MRA at Low Field," JMRI (Accepted November 1998)  [PubMed Abstract]
Hoogeveen, RM Bakker CJ, Viergever MA, "Limits to the accuracy of vessel diameter measurement in MR angiography," JMRI 8: 1228-1235 (1998)  [PubMed Abstract]
Holdsworth, D.W., Norley, C.J.D., Frayne, R., Steinman, D.A., and Rutt, B.K., "Characterization of common carotid artery blood-flow waveforms in normal subjects," accepted for publication in Phys. Meas., (Dec 1998)  [PubMed Abstract]
Hoogeveen,RM , Bakker CJ, Viergever MA, "MR digital subtraction angiography with asymmetric echo acquisition and complex subtraction: improved lumen and stenosis visualization," MRI17: 305-311 (1999)  [PubMed Abstract]
Hoogeveen, RM, Bakker CJ, Viergever MA, "MR phase-contrast flow measurement with limited spatial resolution in small vessels: value of model-based image analysis," MRM 41: 520-528(1999)  [PubMed Abstract]
Bakker, CJ, Hoogeveen RM, Viergever MA, "Construction of a protocol for measuring blood flow by two-dimensional phase-contrast MRA," JMRI 9: 119-127 (1999)  [PubMed Abstract]
Moore, J.A., Steinman, D.A., Holdsworth, D.W., Ethier, C.R., "Accuracy of computational hemodynamics in complex geometries reconstructed from MRI," Annals of Biomed. Eng. 27 (1) 32-41(1999)  [PubMed Abstract]
Lee, MK, Drangova, M, Holdsworth, DW, Fenster, A. “Application of dynamic computed tomography for measurements of local aotric elastic modulus”  Med. Biol. Eng. Comput., 1999, 37, 13-24
Smith, RF, Rutt, BK Holdsworth, DW. “Anthropomorphic Carotid Bifurcation Phantom for MRI Applications”  JMRI 10: 533-544 (1999)
Stewart, SF.  “A rotating torus phantom for assessing color Doppler accuracy.”  Ultrasound Med & Biol, 1999;25:1251-1264.
Holdsworth, DW, Drangova, M, Fenster, A. “Quantitative angiographic blood-flow measurement using pulsed intra-arterial injection” Med. Phys. 26 (10), October 1999
Steinman DA, Poepping TL, Tambasco M, Rankin RN, Holdsworth DW.  “Flow patterns at the stenosed carotid bifurcation: effect of concentric versus eccentric stenosis.”  Ann Biomed Eng 2000 Apr;28(4):415-23
Zahalka, A, Fenster, A. “An automated segmentation method for three-dimensional carotid ultrasound images” Phys. Med. Biol. 46 1321-1342 (2001)
Frangi, AF, Niessen, WJ, Nederkoorn, PJ, Bakker, J, Mali, WP, and Max A. Viergever, “:Quantitative Analysis of Vascular Morphology Frpom 3D MR Angiograms: In Vitro and In Vivo Results,”Magnetic Resonance in Medicine 45:311-322 (2001)
Dabrowski, W, Dunmore-Buyze, J, Cardinal, HN, Fenster, A. “A Real Vessel Phantom For Flow Imaging: 3-D Doppler Ultrasound Of Steady Flow” Ultrasound in Med. & Biol., Vol. 27, No. 1, pp, 135-141, 2001
Poepping TL, Nikolov N, Rankin N, Lee M, Holdsworth DW.,   “An in vitro system for Doppler ultrasound flow studies in the stenosed carotid artery bifurcation”  Ultrasound Med Biol 2002 Apr;28(4):495-506
Jeomg, EK, Parker, DL, Tsuruda, JS, Won, JY.  “Reduction of Flow-Related Signal Loss in Flow-Compensated 3D TOF MR Angiography, Using Variable Echo Time (3D TOF-VTE)”  Magnetic Resonance in Medicine 48:667-676 2002
Poepping TL, Nikolov HN, Rankin RN, Lee M, Holdsworth DW.  An in vitro system for Doppler ultrasound flow studies in the stenosed carotid artery bifurcation. Ultrasound Med Biol. 2002 Apr;28(4):495-506
J Magn Reson Imaging. 2003 Feb;17(2):153-62.
Papathanasopoulou P, Zhao S, Köhler U, Robertson MB, Long Q, Hoskins P, Xu XY, Marshall I., “MRI measurement of time-resolved wall shear stress vectors in a carotid bifurcation model, and comparison with CFD predictions.” J Magn Reson Imaging. 2003 Feb;17(2):153-62.
Steinman DA, Milner JS, Norley CJ, Lownie SP, Holdsworth DW.  “Image-based computational simulation of flow dynamics in a giant intracranial aneurysm.”  AJNR Am J Neuroradiol. 2003 Apr;24(4):559-66.
Poepping TL, Nikolov HN, Thorne ML, Holdsworth DW.  “A thin-walled carotid vessel phantom for Doppler ultrasound flow studies.” Ultrasound Med Biol. 2004 Aug;30(8):1067-78
Khoshniat M, Thorne ML, Poepping TL, Hirji S, Holdsworth DW, Steinman DA.  “Real-time numerical simulation of Doppler ultrasound in the presence of nonaxial flow.” Ultrasound Med Biol. 2005 Apr;31(4):519-28.
Summers PE, Holdsworth DW, Nikolov HN, Rutt BK, Drangova M.  “Multisite trial of MR flow measurement: phantom and protocol design.” J Magn Reson Imaging. 2005 May;21(5):620-31.
Ford MD, Stuhne GR, Nikolov HN, Habets DF, Lownie SP, Holdsworth DW, Steinman DA.  “Virtual angiography for visualization and validation of computational models of aneurysm hemodynamics.” IEEE Trans Med Imaging. 2005 Dec;24(12):1586-92.
Ford MD, Lee SW, Lownie SP, Holdsworth DW, Steinman DA.  “On the effect of parent-aneurysm angle on flow patterns in basilar tip aneurysms: towards a surrogate geometric marker of intra-aneurismal hemodynamics.” J Biomech. 2008;41(2):241-8.
Thorne ML, Poepping TL, Rankin RN, Steinman DA, Holdsworth DW. “Use of an ultrasound blood-mimicking fluid for Doppler investigations of turbulence in vitro.” Ultrasound Med Biol. 2008 Jul;34(7):1163-73. Epub 2008 Mar 14.
Wong EY, Thorne ML, Nikolov HN, Poepping TL, Holdsworth DW.  “Doppler ultrasound compatible plastic material for use in rigid flow models.” Ultrasound Med Biol. 2008 Nov; 34 (11):1846-56. . Epub 2008 Mar 14. Erratum in: Ultrasound Med Biol. 2008 Nov;34(11):1872.
Ford MD, Nikolov HN, Milner JS, Lownie SP, Demont EM, Kalata W, Loth F, Holdsworth DW, Steinman DA. “PIV-measured versus CFD-predicted flow dynamics in anatomically realistic cerebral aneurysm models.” J Biomech Eng. 2008 Apr;130(2):021015.
Thorne ML, Poepping TL, Nikolov HN, Rankin RN, Steinman DA, Holdsworth DW. “In vitro Doppler ultrasound investigation of turbulence intensity in pulsatile flow with simulated cardiac variability.” Ultrasound Med Biol. 2009 Jan;35(1):120-8. Epub 2008 Oct 31.
Wong EY, Nikolov HN, Thorne ML, Poepping TL, Rankin RN, Holdsworth DW.  “Clinical Doppler ultrasound for the assessment of plaque ulceration in the stenosed carotid bifurcation by detection of distal turbulence intensity: a matched model study.” Eur Radiol. 2009 Nov;19(11):2739-49. Epub 2009 Jun 23
Thorne ML, Rankin RN, Steinman DA, Holdsworth DW.  “In vivo Doppler ultrasound quantification of turbulence intensity using a high-pass frequency filter method.” Ultrasound Med Biol. 2010 May;36(5):761-71. Epub 2010 Apr 9.
Poepping TL, Rankin RN, Holdsworth DW.  “Flow patterns in carotid bifurcation models using pulsed Doppler ultrasound: effect of concentric vs. eccentric stenosis on turbulence and recirculation.” Ultrasound Med Biol. 2010 Jul;36(7):1125-34. Epub 2010 May 5.
Kefayati S, Poepping TL.  “3-D flow characterization and shear stress in a stenosed carotid artery bifurcation model using stereoscopic PIV technique.” Conf Proc IEEE Eng Med Biol Soc. 2010;2010:3386-9.
And more…...............
Intracranial Vascular Phantom (Silicone) Products:
Philippe Gailloud, Michel Muster, Michel Piotin, Florence Mottu, Kieran J. Murphy, Jean H. D. Fasel, and Daniel Rufenacht,  “In Vitro Models of Intracranial Arteriovenous Fistulas for the Evaluation of New Endovascular Treatment Materials”  AJNR Am J Neuroradiology 20:291-295, February 1999
Gailloud, P, Muster, M, Piotin, M, Mottu, F, Murphy, KJ, Fasel, JH, Rufenacht, DA.  “In Vitro Models of Intracranial Arteriovenous Fistulas for the Evaluation of New Endovascular Treatment Materials”  AJNR Am J Neuroradiology 20:291-295, February 1999 
Martin JB, Sayegh Y, Gailloud P, Sugiu K, Spadola L, Khan HG, Fasel JHD, Guimaraens L, Fasel JHD, Theron J, Rüfenacht DA  “In vitro models of human carotid atheromatous disease”  In: Carotid Angioplasty and Stenting. Henry M, Amor M, Théron J, Roubin GS (eds), Europa Edition, Paris, 1998, pp. 199-204
Intracranial Vascular Phantom (Acrylic) Products:
Parlea, L., Fahrig, R., Holdsworth, D.W., and Lownie, S., "An analysis of the geometry of saccular aneurysms," accepted for publication in AJNR (Dec., 1998)  [PubMed Abstract]
Fahrig, R., Nikolov, H., Fox, A.J., and Holdsworth, D.W., "A three-dimensional cerebral vascular flow phantom," Med. Phys. 26 (8), August 1999.
Coronary Tree Phantoms (Stereolithography) Products:
Renaudin, CP, Barbier, B, Roriz, R, Revel, D, Amiel, M. “Coronary Arteries: New Design for Three-dimensional Arterial Phantoms”  Radiology 1994; 190: 579 - 582
Kohler, U, Marshall, I, Robertson, MB, Long, Q, Xu, XY, Hoskins, P. “MRI  Measurement of Wall Shear Stress Vectors in Bifurcation Models and Comparison With CFD Predictions” JMRI 14: 563-573 (2001)
Rickey, DW, Fenster, A,"A Wall-Less Vessel Phantom For Doppler Ultrasound Studies"  Ultrasound Med. & Biol., Vol 21, No. 9, pp. 1163-1176, 1995
Chris J. Bakker, Ph.D. … Henk F. Smits, MD … Clemens Bos, MSc. … Remko van der Weide, MSc. … Karel J. Zuiderveld, Ph.D. … Joop J. van Vaals, Ph.D. … Wenzel F. Hurtak, MSc. … Max A. Viergever, Ph.D., … Willem P. Mali, MD "MR-Guided Ballon Angioplasty: In Vitro Demonstration of the Potential of MRI for Guiding, Monitoring, and Evaluating Endovascular Interventions,"JMRI 8 : 245 - 250 (1998)

P. Gailloud, J.R. Pray, M. Muster, M. Piotin, J.H.D. Fasel and D.A. Rufenacht “An in vitro anatomic model of human cerebral arteries with saccular arterial aneurysms” Surg Radiol Anat (1997) 19 : 119-121